p607fig16.40 Effects of medial septum (MS) inactivation on grid cells. (a) Each row shows data and different data-derived measures of grid cell responsiveness, starting from the left with the baseline response to the middle column with maximal inhibition. (b) Data showing the temporary reduction in the gridness scores during MS inactivation, followed by recovery. (c) Simulation of the collapse in gridness, achieved by reduction in cell response rates to mimic reduced cholinergic transmission. (d,e) Simulations of the reduction in gridness scores in (d) by reduction of cell response rates, in (e) by changing the leak conductance. See the text for details.
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