p560fig15.30 The inhibitory pathway from striosomal cells to the SNc is able to inhibit the SNc when a reward occurs with expected timing and magnitude.<BR>||  Inhibitory pathway.  Learning: CS-striosomal LTP occurs due to a three-way coincidence [An active CS working memory input, a Ca2+ spike, a dopamine burst]; Signaling: The delayed Ca2+ spike facilitates striosomal-SNc inhibition;.  Striosomal cells learn to predict both timing and magnitude of reward signal to cancel it: reward expectation;.  Conditioned stimuli (CS) LTP-> Striosomal cells <- dopamine | (-)-> SNc->.